Systemic Lupus Erythematosus

A chronic, inflammatory, connective tissue disease that can affect many organs including the joints, skin, heart, lungs, kidneys, and nervous system. It is marked by many different symptoms; however, not everyone with SLE has all of the symptoms.

Curated Regions

More details about the regions are available here.

Region	Position	Genes	Markers	Diseases
SLE 1q23.3	chr1:161419627-161668253	FCGR2A	rs1801274	AS CRO SLE UC IBD
SLE 1p13.2	chr1:113296527-114009223	PTPN22	rs2476601	ATD CRO JIA RA SLE T1D AA VIT
SLE 1q42.3	chr1:235651207-235928298	LYST	rs9782955	SLE
SLE 1q32.1	chr1:206709013-206867232	IL10	rs3024505	CRO SLE T1D UC IBD
SLE 1q25.3	chr1:183277955-183610838	SMG7 NCF2	rs17849501	SLE
SLE 1q25.3	chr1:184627672-184944870	EDEM3	rs10911628	SLE
SLE 1q25.1	chr1:173128850-173331701	TNFSF4	rs704840 rs2205960	SLE
SLE 2q34	chr2:212899279-213151021	IKZF2	rs3768792	SLE
SLE 2q24.2	chr2:162104363-162502867	IFIH1	rs2111485	PSO SLE T1D UC IBD VIT
SLE 2q32.3	chr2:190990148-191143008	STAT4	rs7574865 rs11889341	PBC RA SLE
SLE 3p14.3	chr3:58172132-58566602	PXK ABHD6	rs9311676	SLE
SLE 3q25.33	chr3:159973324-160104880	IL12A	rs564799	PBC SLE
SLE 4q24	chr4:101780701-102172329	BANK1	rs10028805	SLE
SLE 5q31.1	chr5:134055825-134440162	SKP1 TCF7	rs7726414	SLE
SLE 5q33.1	chr5:151012930-151104264	TNIP1	rs10036748 rs7708392	SLE
SLE 5q33.3	chr5:160397457-160540930	MIR146A MIR3142HG	rs2431697	SLE SJO
SLE MHC	chr6:31600692-32218019		rs1270942	CEL SLE
SLE 6q21	chr6:106100256-106180825	ATG5 PRDM1	rs6568431	SLE
SLE 6p21.31	chr6:34537417-35395980	UHRF1BP1	rs9462027 rs11755393	SLE
SLE MHC	chr6:32350867-32714358	HLA-DRB1	rs3135394 rs9271366	CEL SLE UC SJO
SLE 6q23.3	chr6:137568592-137974695	TNFAIP3	rs5029937 rs6932056 rs6920220	CEL RA SLE T1D UC IBD
SLE 7p15.1	chr7:28080094-28222707	JAZF1	rs849142	CRO SLE
SLE 7q32.1	chr7:128911686-129137466	TNPO3 IRF5	rs2070197 rs10488631 rs4728142	PBC RA SLE UC IBD SJO
SLE 7p12.2	chr7:50206640-50325467	IKZF1	rs4917014	SLE
SLE 8p23.1	chr8:11426026-11546260	BLK	rs2736340	SLE
SLE 10q11.23	chr10:48742291-48932543	WDFY4	rs2663052	SLE
SLE 10q21.2	chr10:62002144-62170402	ARID5B	rs4948496	SLE
SLE 11p15.5	chr11:406483-721570	IRF7 PHRF1	rs12802200 rs4963128	SLE
SLE 11q24.3	chr11:128558890-128692203	FLI1 ETS1	rs7941765	SLE
SLE 11q13.4	chr11:71400136-71530651	DHCR7 NADSYN1	rs3794060	SLE
SLE 11p13	chr11:34998708-35142427	CD44	rs2732549	SLE
SLE 12q24.12	chr12:111281256-112592683	SH2B3	rs10774625	CEL PBC SLE T1D
SLE 12q24.33	chr12:128772462-128861985	SLC15A4	rs1059312	SLE
SLE 14q24.1	chr14:68071518-68480615	RAD51B	rs4902562	SLE
SLE 15q26.2	chr15:97010453-97107241	SPATA8	rs8023715	SLE
SLE 15q14	chr15:38253598-38524632	FAM98B	rs11073328	SLE
SLE 15q24.2	chr15:74435612-75197474	CSK	rs2289583	SLE
SLE 16q24.1	chr16:85927444-85950409	IRF8	rs11644034	SLE
SLE 16p13.13	chr16:10923201-11215894	SOCS1 CIITA	rs9652601	MS PBC SLE T1D
SLE 16p11.2	chr16:30754926-31373327	ITGAM	rs11860650 rs34572943 rs9888739	SLE
SLE 17p13.2	chr17:4788077-4894010	PLD2	rs2286672	SLE
SLE 17q12	chr17:39219977-40074859	IKZF3	rs2941509	SLE
SLE 19p13.2	chr19:10285007-10517872	TYK2	rs2304256	PBC PSO SLE T1D
SLE 20q13.13	chr20:49792078-50046045	RNF114	rs11697848	SLE
SLE 22q11.21	chr22:21454896-21649639	UBE2L3	rs5754217 rs7444	CEL CRO SLE
SLE Xq28	chrX:153797346-154125011	IRAK1 MECP2	rs1734787 rs2269368	RA SLE
SLE Xp21.2	chrX:30513441-30624914	CXorf21	rs887369	SLE

Curated Studies

Study ID	Title	Publication	Diseases
015	Whole Genome Association Study	Gateva Nat. Genet., 2009-10-18	SLE
037	Whole Genome Association Study	Armstrong Genes Immun., 2014-05-29	SLE
047	Whole Genome Association Study	Bentham Nat. Genet., 2015-10-26	SLE