Overview

IDAllelesLocationGenome BuildSource
rs2228145A/C,Tchr1: 15445449438dbsnp146
rs2228145A/C,T chr1: 154426970 37dbsnp146_grch37
rs8192284T/G chr1: 154454494 38ImmunoChip
rs8192284T/G chr1: 154426970 37ImmunoChip
rs8192284T/G chr1: 152693594 36ImmunoChip

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Historical Ids

Old Marker IDNew Marker IDCurrent Marker IDdbSNP Build
rs117579727rs2228145rs2228145132
rs8192284rs2228145rs2228145130
rs58037860rs2228145rs2228145130
rs52837205rs8192284rs2228145128

Criteria

rs2228145 meets the following criteria:

Criteria Name
Details
Disease Tags
Marker is GW-Significant in a Study 
Marker is in r2>0.8 with an index SNP 
Marker is an index SNP in a Region 

Functional Information

Gene function properties for rs2228145 as derived from dbSNP:
  • in intron
  • has reference
  • has non-synonymous missense
Gene(s) at location of variation:  IL6R 

Study

Studies containing regions of association that span this marker are shown below. Please note that when making comparisons across studies, that they may vary in terms of size, genotyping platform, and exclusion criteria. If the 'Odds Ratio' is less than 1 then the region is protective (alleles are marked as blue) otherwise it is susceptible (alleles marked as red).

StudyPublicationDiseaseRegionMarkerAllelesP-valueORMAFGene(s)

Populations

Populations data from Ensembl 1000 Genome data release May 2013:

Linkage Disequilibrium Statistics

LD Search Options

Linkage disequilibrium (LD) statistics are calculated for rs2228145, using the 1000 genomes data release May 2013. Calculations are performed with the snpStats R library, covering 1Mb either side of the marker; and with the following filters applied: MAF > 0.01, call rate < 0.9, and chi-squared test for deviation from HWE > 25.