Overview

IDAllelesLocationGenome BuildSource
rs4445406T/Cchr1: 260796138dbsnp146
rs4445406T/C chr1: 2539400 37dbsnp146_grch37
imm_1_2529260A/G chr1: 2607961 38ImmunoChip
imm_1_2529260A/G chr1: 2539400 37ImmunoChip
imm_1_2529260A/G chr1: 2529260 36ImmunoChip

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Historical Ids

Old Marker IDNew Marker IDCurrent Marker IDdbSNP Build
rs58538957rs4445406rs4445406130

Criteria

rs4445406 meets the following criteria:

Criteria Name
Details
Disease Tags
Marker is GW-Significant in a Study 
Marker is in r2>0.8 with an index SNP 
Marker is an index SNP in a Region 

Functional Information

Gene function properties for rs4445406 as derived from dbSNP:
  • in 5prime gene region
  • in intron
Gene(s) at location of variation:  MMEL1 

Study

Studies containing regions of association that span this marker are shown below. Please note that when making comparisons across studies, that they may vary in terms of size, genotyping platform, and exclusion criteria. If the 'Odds Ratio' is less than 1 then the region is protective (alleles are marked as blue) otherwise it is susceptible (alleles marked as red).

StudyPublicationDiseaseRegionMarkerAllelesP-valueORMAFGene(s)

Populations

Populations data from Ensembl 1000 Genome data release May 2013:

Linkage Disequilibrium Statistics

LD Search Options

Linkage disequilibrium (LD) statistics are calculated for rs4445406, using the 1000 genomes data release May 2013. Calculations are performed with the snpStats R library, covering 1Mb either side of the marker; and with the following filters applied: MAF > 0.01, call rate < 0.9, and chi-squared test for deviation from HWE > 25.