18p11 (chr18:12721854..12932218)

The Chiamo-scored data was scanned for the best 500 markers across the entire genome. LD analysis was carried out on these markers, and regions of strong LD were identified, using different r² cut-off values. These regions were then examined for genes, and the presence of markers within genes was determined.

Analysis Parameters

• The LD analysis was performed using the HapMap CEU population (build 21a), location data from build NCBI36, and with a 1Mb flanking sequence either side of the marker.
• The definition of a gene location includes a 3kb flanking region either side of the gene. An 'Entire Gene' in this context means that the whole gene is contained within the LD region; 'Overlapping' is when only a portion of the gene is in the LD region.
• LD files were created with Haploview (Haploview: analysis and visualization of LD and haplotype maps. Barrett JC, Fry B, Maller J, Daly MJ. Bioinformatics. 2005).