Getting Started with T1DBase

T1DBase focuses on two research areas in type 1 diabetes (T1D): the genetics of T1D susceptibility and beta cell biology. This site provides tools which allow scientists to analyze, store, and share this T1D data with other scientists.

There are two main ways to access information in T1DBase:

Use the Search box in the upper right corner to search for genes, genetic markers (SNPs), or candidate regions. The results page has a summary of each gene, marker, or candidate region that matched the search term and provides links to pages with more information. It works best to search for identifiers, such as gene symbols (e.g., INS or PDX-1), RS numbers for SNPs, and so forth. T1DBase does not do full text searching.
Click on a link in the list on the left side of the page (called the "left-hand navigation bar"). Most links point to pages that provide access to specific kinds of information, for example, summary information from the Wellcome Trust Case Control Consortium (WTCCC), or microarray gene expression data from a large number of studies.

You can also click on the idiogram on the T1DBase home page to see information about genomic regions identified through genetic studies. You can click on a chromosome or the colored bars to the right of each chromosome to obtain further detail on a susceptibility region. T1DBase has idiograms for human, mouse, and rat; links in the upper right corner of the idiogram allow you to select which organism is displayed.

Getting Started with the Left-Hand Navigation Bar

Genetics

T1DMart. Query marker and genotype data using positional, genotypic, or subject-related criteria. More Information
WTCCC Summary Data. Access data from the Wellcome Trust Case Control Consortium.
NOD Strain Information. Visualize NOD congenic strains.

Genomics

GBrowse. Genome browser.
BLAT Search. Search human and mouse T1D susceptibility region sequence using Kent's BLAT algorithm. More Information

Gene expression

Beta Cell Gene Bank. Expertly curated annotations of beta cell genes. More Information
Beta Cell Gene Atlas. Data on gene expression in beta cells, islets, and related cell types. More Information
Microarray Viewer. Heatmap display of gene expression data. More Information
Tissue Expression. Tissue-specific gene expression data. More Information

General

Gene Dossier. Concise table view of a list of genes emphasizing T1D-specific data. More Information
Connect the Dots. Translator for biological identifiers. More Information
Poster Pages. Discussions of scientific topics by T1DBase staff in collaboration with contributing scientists. More Information
My T1DBase. Lists of genes, markers, and candidate regions. More Information

Networks & Pathways

Cytoscape. View and analyze protein interaction networks. More Information
Pathway Builder. Draw your own networks using Cytoscape. More Information
KEGG Pathways. Lists of genes in KEGG pathways.

Logging into T1DBase

You are welcome to use T1DBase without logging in, but certain features will not be available. There is a Log In link in the upper right corner of most T1DBase pages, directly below the Search box. Registering for an account is simple and fast. If you want to use all features of T1DBase (except access to private data) without registering, you can login with a guest account. More Information