A genome-wide association scan comprising a total of 2,657 unrelated Sardinian Multiple Sclerosis (MS) patients and 2,877 controls using the Affymetrix genotyping platform. A total of 575,678 unique SNPs were genotyped. To maximise genome-wide coverage, the MACH algorithm was used to impute ~6M SNPs using HapMap CEU and TSI haplotypes as well as 56 unrelated individuals of European decent from the 1000 Genomes Project. Association at genome-wide significance (P<5x10-8) was confirmed for the HLA region, showing strong correlation for the DRB1*0301-DQB1*0201 haplotype as previously found. Of the non-HLA SNPs only one showed genome-wide significance, rs9657904 located in intron 1 of CBLB on chromosome 3q13.11.
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GDXHsS00043 meets the following criteria: